Disfunción vascular durante el embarazo en mujeres con síndrome del ovario poliquístico

Se ha propuesto una relación entre síndrome de los ovarios poliquísticos (SOP) y trastornos hipertensivos del embarazo.

En 22 casos de SOP con embarazos simples se reclutaron a als 11-13 semanas de embarazo y se compararon los resultados con otros grupo de gestantes similares , pero sin SOP, parfa estudair la evolución de la tensión arterial. Las embarazadas con SOP tuvieron tensión arterial más alta y menor elasticidad arterial como parte de la adaptación al embarazo.

Human Reproduction 2007 22(6):1532-1539;
Vascular dysfunction during pregnancy in women with polycystic ovary syndrome
Shan Hu1, Andrew Leonard1, Alex Seifalian2 and Paul Hardiman1,3

BACKGROUND: An association has been proposed between polycystic ovary syndrome (PCOS) and pregnancy-induced hypertensive disorders. Ambulatory blood pressure and carotid artery elasticity were therefore prospectively investigated in matched PCOS and control pregnancies.
METHODS: Twenty two PCOS–control subject pairs with singleton pregnancies, matched for age, body mass index, parity and ethnicity, were recruited in the first trimester (T1, 11–13 weeks). Ambulatory blood pressure recording for 24 h and carotid artery ultrasound for elasticity estimation were performed in T1 and in the second (T2, 22–24 weeks) and third (T3, 32–34 weeks) trimesters.
RESULTS: At nearly all time points during gestation, ambulatory systolic, diastolic and mean arterial pressures were elevated in PCOS versus control pregnancies. Carotid artery stiffness index was greater and compliance was less in PCOS pregnancies compared with controls. Differences in night-time systolic pressure and carotid artery elasticity were greatest in T3. PCOS also increased the incidence of pregnancy-induced hypertension (6 of 22 cases versus 0 of 22 in controls; P = 0.011).
CONCLUSIONS: Pregnant women with PCOS have higher baseline ambulatory blood pressure and impaired arterial elasticity, suggestive of disturbed vascular adaptation to pregnancy.

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